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目的分析血清抗线粒体抗体(AMA)阳性患者的实验室指标,探讨抗线粒体抗体的诊断价值。方法将AMA阳性患者63例,分为原发性胆汁性肝硬化(PBC)47例和非PBC 16例,分析每组生化、免疫学指标。结果与47例PBC患者比较,16例非PBC患者ALP、r-GT升高无PBC组明显(P<0.001)。ANA、抗dsDNA阳性率无PBC组高(P<0.01)。结论 AMA在PBC患者中检出率极高,但AMA并不只出现在PBC患者血清中。在肝胆疾病、其他疾病患者血清中亦可检出,二者实验室检查有差异。
Objective To analyze the laboratory indexes of serum anti-mitochondrial antibody (AMA) -positive patients and investigate the diagnostic value of anti-mitochondrial antibodies. Methods 63 patients with AMA positive were divided into primary biliary cirrhosis (PBC) 47 cases and non-PBC 16 cases. The biochemical and immunological indexes of each group were analyzed. Results Compared with 47 PBC patients, ALP and r-GT increased in 16 non-PBC patients without PBC (P <0.001). ANA, positive rate of anti-dsDNA no PBC group (P <0.01). Conclusion The detection rate of AMA in PBC patients is very high, but AMA does not only appear in the serum of PBC patients. Hepatobiliary disease, other diseases can also be detected in the serum of patients, both laboratory tests are different.