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粒细胞吞噬和杀灭入侵细菌时,借助于呼吸链中活性氧的代谢产物如O_2~-和H_2O_2的作用。活性氧的生成伴有化学发光。正常状态细胞粒细胞数与化学发光量存在较好的相关性。本实验测定了经不同剂量照射后的不同时间,小鼠外周血中粒细胞数及化学发光量的改变,发现上述相关性消失,发光量随照射剂量及照射后测定时间的不同而有差异。 照射用250kV-X线机,15mA,2mmCu半价层,焦皮距75cm,剂量率0.6Gy/min。用1～8Gy
When granulocytes phagocytize and kill invading bacteria, they use the active oxygen metabolites such as O 2 - and H 2 O 2 in the respiratory chain. Reactive oxygen species are accompanied by chemiluminescence. There is a good correlation between the number of cells and the amount of chemiluminescence in the normal state. In this experiment, we measured the changes of the number of neutrophils and the amount of chemiluminescence after different doses of irradiation, and found that the above correlation disappeared. The amount of luminescence was different with the irradiation dose and the time after irradiation. Irradiation with 250kV-X ray machine, 15mA, 2mmCu half price layer, focal distance 75cm, dose rate 0.6Gy / min. With 1 ~ 8Gy