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目的观察比较补肾祛瘀益智汤和尼莫地平治疗糖尿病患者认知功能障碍的疗效。方法选取医院收治的糖尿病认知功能障碍患者88例,随机分为试验组和对照组,每组44例。对照组给予尼莫地平治疗,试验组给予自拟补肾祛瘀益智汤治疗。根据长谷川痴呆修改量表(HDS)、记忆商(MQ)、简易精神状态检查表(MMSE)对患者进行量表评分,并比较2组治疗效果。结果试验组总有效率为81.82%,明显高于对照组的56.82%(P<0.01)。治疗后,2组HDS、MQ、MMSE评分值较治疗前均提高(P<0.05);试验组较对照组提高更明显,差异有统计学意义(P<0.05)。结论补肾祛瘀益智汤对糖尿病患者认知功能障碍具有显著疗效,适合在临床上推广应用。
Objective To observe and compare the therapeutic effects of Bushen Qiyu Decoction and nimodipine on cognitive dysfunction in diabetic patients. Methods Eighty-eight patients with cognitive dysfunction of diabetes admitted to hospital were randomly divided into experimental group and control group, 44 cases in each group. The control group was treated with nimodipine, and the experimental group was treated with self-made Bushen Quyu Yizhi Decoction. Patients were scored on the basis of Hasegawa dementia modification scale (HDS), memory card (MQ), and mini-mental status checklist (MMSE), and the treatment effect was compared between the two groups. Results The total effective rate of the experimental group was 81.82%, which was significantly higher than that of the control group (56.82%, P <0.01). After treatment, the scores of HDS, MQ and MMSE in two groups were significantly higher than those before treatment (P <0.05). The experimental group was more obvious than the control group, with significant difference (P <0.05). Conclusion Bushen Quyu Yizhitang has a significant effect on cognitive dysfunction in diabetic patients, and is suitable for clinical application.