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目的观察口服α受体阻滞剂能否有效缓解前列腺穿刺术后的排尿不适症状。方法 2010年1月至2012年3月我科50例怀疑为前列腺癌的住院患者[(63.1±6.6)岁]随机分为试验组、对照组,每组25例,试验组在穿刺前1 d至穿刺后7 d每天口服4 mg甲磺酸多沙唑嗪控释片,监测、比较2组患者穿刺前1 d及穿刺后1、7 d的国际前列腺症状评分表(IPSS)评分、最大尿流率数值。结果与穿刺前基线相比,穿刺后1、7 d,试验组IPSS评分分别由(14.21±7.62)分上升至(18.43±5.98)分、(17.94±7.14)分,对照组由(16.49±8.33)分上升至(21.44±4.75)、(19.02±6.57)分;实验组最大尿流率由(9.32±6.82)mL/s下降至(7.08±9.35)、(8.36±11.21)mL/s,对照组由(9.78±5.45)mL/s下降至(5.64±10.42)、(8.85±10.94)mL/s。试验组穿刺后1 d IPSS评分低于对照组(P<0.05),最大尿流率高于对照组(P<0.05)。结论口服α受体阻滞剂对缓解前列腺穿刺术后的排尿不适症状有一定效果。
Objective To observe whether oral alpha blockers can effectively relieve urinary symptoms after prostate puncture. Methods From January 2010 to March 2012, 50 hospitalized patients with suspected prostate cancer [(63.1 ± 6.6) years old] in our department were randomly divided into experimental group and control group, with 25 cases in each group. On the 7th day after the punctures, 4 mg of doxazosin mesylate tablets were orally administered daily to monitor and compare the IPSS scores at 1 d before and 1 and 7 days after puncture. Flow rate values. Results Compared with the pre-puncture baseline, the IPSS score of the experimental group increased from (14.21 ± 7.62) points to (17.44 ± 7.14) points and (16.49 ± 8.33) points ) Increased to (21.44 ± 4.75) and (19.02 ± 6.57) min, respectively. The maximum flow rate of the experimental group decreased from (9.32 ± 6.82) mL / s to (7.08 ± 9.35) and (8.36 ± 11.21) mL / Group decreased from (9.78 ± 5.45) mL / s to (5.64 ± 10.42) and (8.85 ± 10.94) mL / s, respectively. The IPSS score of the experimental group on 1 d after puncture was lower than that of the control group (P <0.05), and the maximum urinary flow rate was higher than that of the control group (P <0.05). Conclusion Oral α-blockers have some effect on relieving urinary symptoms after prostate puncture.