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目的:传递体作为双氯芬酸钠经皮渗透载体的体外研究。方法:采用改良Franz扩散池体外经皮渗透实验技术,对双氯芬酸钠传递体、普通脂质体及其凝胶剂的经皮渗透作用进行了比较。结果:24 h后双氯芬酸钠传递体、普通脂质体及其凝胶剂的累积透皮量分别为598.16μg·cm-2,209.15μg·cm-2,391.33μg·cm-2。皮肤内滞留量Q滞分别为191.54μg·cm-2,419.28μg·cm-2,8.77μg·cm-2。结论:以传递体作为双氯芬酸钠的载体可以促进其经皮渗透,且皮内的滞留药物还表现出一定的贮库效应。而普通脂质体不能很好地促进药物透过皮肤,但利于药物在皮内的大量滞留。
OBJECTIVE: The in vitro study of delivery as diclofenac sodium transdermal delivery vehicle. Methods: The transdermal permeation of diclofenac sodium mediators, common liposomes and their gels were compared by using the modified Franz diffusion cell in vitro transdermal permeation test. RESULTS: After 24 h, the cumulative transdermal doses of diclofenac sodium mediators, common liposomes and their gels were 598.16 μg · cm-2 and 209.15 μg · cm-2,391.33 μg · cm-2, respectively. Q retention of skin retention was 191.54μg · cm-2,419.28μg · cm-2,8.77μg · cm-2. CONCLUSION: The transdermal delivery of diclofenac sodium can promote its transdermal penetration, and the intradermal drug retention also shows some depot effect. Ordinary liposomes can not promote the drug through the skin well, but it is conducive to a large number of drug retention in the skin.