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目的:探讨无症状性脑梗死(SBI)患者认知功能及抑郁与事件相关电位变化的关系。方法:选取2014年6月~2015年6月收治的70例SBI患者,选择HAMD和MMSE检查,采取ERP电位检测,同时和65例非脑梗死对比分析。结果:通过两组患者的Fenix对比,SBI组33例患者的HAMD评分>17分,是抑郁亚组。同时,有37例患者的HAMD评分<17分,是非抑郁亚组。另外,SBI组患者MMSE评分为(16.9±1.6)分,比对照组(24.9±1.4)分明显要低,认知障碍发生率52.4%,比对照组10.2%明显要高。SBI组患者和对照组患者对比,SBI患者潜伏期显著性延长,波幅明显降低。针对SBI组患者,非抑郁亚组患者MMSE评分为(21.2±2.2)分,认知障碍率19.2%,抑郁亚组患者MMSE评分(14.6±1.0)分,认知障碍率91.4%,抑郁亚组P3潜伏期显著性延长,波幅出现明显下降。结论:对于无症状性脑梗死患者,基本上认知功能存在障碍,同时,随着抑郁程度不断增高,认知障碍度也愈加明显,通过ERP检查,可为无症状性脑梗死的诊断提供准确依据,值得临床运用。
Objective: To investigate the relationship between cognitive function and depression and event-related potentials in patients with asymptomatic cerebral infarction (SBI). Methods: Seventy patients with SBI who were admitted to our hospital from June 2014 to June 2015 were enrolled in this study. HAMD and MMSE were used to detect ERP and ERP was compared with 65 non-cerebral infarction patients. Results: Fenix comparison of two groups of patients, SBI group of 33 patients with HAMD score> 17 points, is a depression subgroup. In the meantime, 37 patients had a HAMD score <17, which was a non-depressed subgroup. In addition, the score of MMSE in SBI group was (16.9 ± 1.6) points, which was significantly lower than that in control group (24.9 ± 1.4). The incidence of cognitive impairment was 52.4%, which was significantly higher than 10.2% in control group. SBI patients and control patients, SBI patients significantly longer latency, amplitude was significantly lower. In SBI group, MMSE score was (21.2 ± 2.2), cognitive impairment rate was 19.2% in non-depression group, MMSE score was 14.6 ± 1.0 in depression group, cognitive impairment rate was 91.4%, depression group P3 latency significantly longer, amplitude decreased significantly. CONCLUSIONS: Essential cognitive impairment exists in asymptomatic patients with cerebral infarction. At the same time, as the level of depression increases, the degree of cognitive impairment is also more pronounced. ERP testing can provide accurate diagnosis of asymptomatic cerebral infarction Basis, it is worth clinical application.