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目的:探讨鞘膜囊内注射药物后对睾丸生长发育的影响。方法:将5周龄 Wistar 大白鼠40只,随机分成4组,用手术解剖出右睾丸后,分别将其浸泡于99%乙醇、30%尿素、5%四环素、生理盐水溶液内5分钟,然后放回阴囊。喂养2个月,再分别切取各组睾丸进行重量、体积及组织学等检查。结果:显示乙醇、尿素、四环素溶液组的睾丸不但其重量和体积明显低于生理盐水组。而且组织学上也有明显的损害。结论:鞘膜囊内注射药物对幼鼠睾丸造成了损害。提示不宜进行鞘膜囊内注射药物治疗小儿鞘膜积液。
Objective: To investigate the influence of intrathecal drug injection on testicular growth and development. Methods: 40 Wistar rats of 5 weeks old were randomly divided into 4 groups. After the right testes were dissected by surgery, they were soaked in 99% ethanol, 30% urea, 5% tetracycline and saline for 5 minutes respectively Put back the scrotum. Feeding for 2 months, and then were cut into groups testicular weight, volume and histology and other tests. RESULTS: Testicles in ethanol, urea and tetracycline groups showed significantly lower weight and volume than the saline group. And histologically obvious damage. Conclusion: Intrathecal injection of drug on the testes of young rats caused damage. Tips should not be carried out intrathecal injection of drug treatment of pediatric hydrocele.