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目的认识淋巴结内巨核细胞,并与转移癌鉴别。方法对1例乳腺癌患者腋窝淋巴结内出现的大细胞进行HE形态、免疫组化染色观察并复习文献。结果淋巴结的皮质区及髓质区的窦内及窦旁散在少量大细胞(平均直径50μm,最大者>100μm),这些细胞胞质宽大,嗜酸性,核染色质粗颗粒状或呈分叶状。免疫组化染色:CD61、CD31和F-Ⅷ(+),CD68和AE1/AE3(-)。结论淋巴结内出现巨核细胞非常少见,应根据形态学特点、结合免疫组化结果与转移癌相鉴别。
Objective To understand the megakaryocytes in lymph nodes and differentiate them from metastatic carcinomas. Methods One case of breast cancer patients with axillary lymph nodes appeared in HE morphology, immunohistochemical staining and review the literature. Results Small numbers of macrophages (median diameter 50μm, maximum> 100μm) were scattered in the sinus and sinus of the cortex and medulla of lymph nodes. The cells were cytoplasm with large cytoplasm, eosinophilic and nuclear chromatin coarse or lobulated . Immunohistochemical staining: CD61, CD31 and F-VIII (+), CD68 and AE1 / AE3 (-). Conclusion The occurrence of megakaryocytes in lymph nodes is very rare. According to the morphological characteristics, immunohistochemistry and differential diagnosis of metastatic carcinoma should be used.