Based on the theory of finite element analysis, an inverse analysis model for the comprehensive medium parameters of the Qinghai-Tibet Plateau is set up. With the help of GPS velocity field, the comprehensive crustal medium parameters of the plateau are inversely analyzed and the characteristics of the related movement macroscopically simulated. It is then concluded that the tectonic deformation of the plateau is mainly in the form of a N-S compression accompanied by an E-W stretching, and the present tectonic setting of the plateau should be the result of the collision between the Indian and the Eurasian continents during the Cenozoic.