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用戊二醛将5-Fu与抗AFP IgG联接。该免疫联接物体外细胞毒试验表明对产生人AFP的Alexander细胞的细胞毒作用比单纯药物增强约2000倍,而对AFP阴性的K_(562)细胞的细胞毒作用与单纯药物和单纯抗体无明显差异。5例病理诊断为肝细胞肝癌,AFP阳性病人用5-Fu-抗AFPIgG免疫联接物治疗,结果有2例病人血清AFP含量下降。未发生变态反应,亦未见有明显副作用及对肝肾的损害。
5-Fu was coupled to anti-AFP IgG using glutaraldehyde. The cytotoxicity test of this immuno-linked entity revealed that the cytotoxicity of the human AFP-producing Alexander cells was about 2000-fold stronger than that of the drug alone, whereas the cytotoxicity of the AFP-negative K562 cells was not obvious with the drugs alone and the antibodies alone. difference. Five cases of pathological diagnosis of hepatocellular carcinoma, AFP positive patients with 5-Fu-anti-AFPIgG immunoconjugate treatment, the results of two cases of patients with serum AFP levels decreased. No allergic reactions occurred, and no obvious side effects and damage to the liver and kidneys were observed.