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目的 探讨家庭医师管理模式下干预糖调节受损（IGR）患者的转归情况。方法 对上海闵行区梅陇社区随机抽取1353例成年常住居民，筛查糖调节受损（IGR）者，入选评估IGR各亚组临床基线特征、稳态模型法（HO‐MA）评估胰岛素抵抗指数（IRI）及β细胞功能指数，家庭医生健康管理1年后，复查75 g葡萄糖耐量试验（OGTT）。结果 1353名居民中，检出IGR患者110例，检出率8．13％。IGR患者中又分为空腹血糖受损组（IFG组，n＝15）、糖耐量受损组（ IGT组，n＝87）及混合糖调节受损组（CGI组，n＝8），各亚组患者年龄、性别、BMI、腰臀比、血压、血脂、比较差别无统计学意义（ P ＞0．05）；三组间 HOM A‐IR指数CGI组最高，HOM A‐β指数IFG组最低（ P ＜0．01）。110例IGR患者转归正常糖耐量57例，仍为IGR 45例，糖尿病8例。结论 IGT是IGR的主要存在形式；家庭医师管理模式下IGR转归为正常糖耐量为51．81％，IGR为40．9％，糖尿病为7．27％。“,”Objective] To explore the turnover of impaired glucose regulation(IGR) interfered by family physician management .[Methods] Totally 1353 adult residents were randomly collected from Meilong community health service center of Minhang district in Shanghai .IGR patients were selected for evaluating clinical baseline characteristics of IGR subgroups .Homeostasis model method(HOMA) was used to assess insulin resistance index(IR) and beta cell function in‐dex .After 1 year of health education by family physicians ,the 75g glucose tolerance test(OGTT) was reexamined .[Re‐sults]Among 1353 residents ,110 patients with IGR were detected and the detection rate was 8 .13% .IGR patients were divided into impaired fasting glucose group(IFG group ,n =15) ,impaired glucose tolerance group(IGT group ,n =87) and complex impaired glucose regulation group(CGI Group ,n=8) .There was no significant difference in age ,sex ,body mass index(BMI) ,waist/hip ratio ,blood pressure and lipids among subgroups( P >0 .05) .HOMA‐IR in CGI group was the highest and HOMA‐βin IFG group was the lowest( P<0 .01) .Among 110 patients with IGR ,57 patients re‐covered normal glucose tolerance ,and 45 patients were still IGR ,and 8 patients developed to diabetes mellitus .[Conclu‐sion]IGT is the main form of IGR .Under family physician management mode ,the rates of IGR turning to normal glucose tolerance ,IGR and diabetes mellitus are 51 .81% ,40 .9% and 7 .27% ,respectively .