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目的探讨硝苯地平对铁负荷大鼠营养代谢的影响。方法 30只SD大鼠随机分为对照组、铁负荷组、硝苯地平组(连续7 d腹腔注射硝苯地平),测定血脂、脂质过氧化指标、血清中铁、钙、锌,以及铁蛋白和维生素E含量。结果硝苯地平组大鼠总胆固醇(TC)、低密度脂蛋白(LDL)分别为1.65、0.96 mmol/L,明显低于铁负荷组1.91,1.14 mmol/L,(P<0.05);血清中铁、铁蛋白分别为(1.321±0.148)mg/L,明显低于铁负荷组(1.573±0.253)mg/L(P<0.01),硒含量为(0.087±0.017)mg/L,高于铁负荷组(0.074±0.012)mg/L(P<0.05)。结论硝苯地平影响铁负荷大鼠的营养代谢,降低铁负荷对机体的损害。
Objective To investigate the effect of nifedipine on nutrition metabolism in iron overload rats. Methods Thirty SD rats were randomly divided into control group, iron load group and nifedipine group (intraperitoneal injection of nifedipine for 7 days). The levels of serum lipids, lipid peroxidation, serum iron, calcium, zinc and ferritin And vitamin E content. Results The levels of total cholesterol (TC) and low density lipoprotein (LDL) in nifedipine group were 1.65 and 0.96 mmol / L respectively, which were significantly lower than those in iron group 1.91 and 1.14 mmol / L (P <0.05) , Ferritin were (1.321 ± 0.148) mg / L respectively, which were significantly lower than those in the iron-loaded group (1.573 ± 0.253 mg / L, P <0.01) Group (0.074 ± 0.012) mg / L (P <0.05). Conclusion Nifedipine can affect the nutritional metabolism of iron-loaded rats and reduce the damage of iron load to the body.