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目的观察中西医结合治疗过敏性紫癜(HSP)的临床疗效。方法将200例HSP患者随机分为3组。中药组45例予中药煎剂治疗,西药组55例予西药治疗,中西医结合组100例予中西药结合治疗。3组均7 d为1个疗程,治疗3个疗程后评价疗效。结果中西医结合组痊愈率均高于中药组和西药组(P<0.05)。中药组、西药组和中西医结合组血小板平均容积(MPV)、血小板分布宽度(PDW)及血小板压积(PCT)均较本组治疗前降低(P<0.05),MPV、PDW、PCT可作为临床疗效评价的参考。3组治疗前后凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(KPTT)比较差异无统计学意义(P>0.05)。结论 MPV、PDW、PCT均增加,与HSP发病呈正相关,提示血小板可能参与HSP发病过程。中西医结合治疗HSP,均符合HSP病机,二者联合应用,既增强了治疗作用,又减少了西药不良反应,取得良好疗效。
Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of Henoch-Schonlein purpura (HSP). Methods 200 patients with HSP were randomly divided into three groups. Chinese medicine group 45 cases of Chinese medicine decoction treatment, 55 cases of Western medicine to western medicine, Integrative Medicine group of 100 cases to Chinese and Western medicine treatment. 3 groups were 7 d for a course of treatment, evaluation of 3 courses of treatment efficacy. Results The cure rate of Integrative Medicine Group was higher than that of Traditional Chinese Medicine and Western Medicine (P <0.05). The mean platelet volume (MPV), platelet distribution width (PDW) and platelet pressure (PCT) of the TCM group, the western medicine group and the integrated traditional Chinese and western medicine group were significantly lower than those before treatment (P <0.05) Reference to clinical efficacy evaluation. Prothrombin time (PT), thrombin time (TT) and activated partial thromboplastin time (KPTT) had no significant difference before and after treatment in the three groups (P> 0.05). Conclusions MPV, PDW, PCT increased, and the incidence of HSP was positively correlated, suggesting that platelets may be involved in the pathogenesis of HSP. The combination of TCM and Western medicine treatment of HSP, are consistent with the pathogenesis of HSP, the combination of both, not only enhance the therapeutic effect, but also reduce the adverse reactions of western medicine, and achieved good results.