积二膦酸类化合物(Gem-diphosphonates)是同一碳原子上连接两个磷酸基团的有机化合物。我们对这类化合物并不陌生,例如次甲基二膦酸(MDP,1)和1-羟基乙义-1,1-二膦酸(EHDP,2)作为核医学诊断剂,在国内已推广应用于骨扫描。但是这类化合物在治疗、预防和诊断上的潜在应用可能,实际上远远超越这一范围,鉴此,本文作一简要介绍。 Gem-diphosphonates are organic compounds that connect two phosphate groups on the same carbon atom. We are familiar with these compounds. For example, methyldiphosphonic acid (MDP, 1) and 1-hydroxyethyl-1,1-diphosphonic acid (EHDP, 2) have been widely used in the country as nuclear medicine diagnostics Applied to bone scan. However, the potential applications of such compounds in therapy, prevention and diagnosis may actually exceed this range. Therefore, this article gives a brief introduction.