卵巢癌基因治疗的研究备受关注,而自杀基因疗法被认为是最有希望的策略之一,其具有一个独特的杀伤机制,即“旁观者效应”,转染了自杀基因的肿瘤细胞被杀死,且周围大量未被转染的肿瘤细胞也被杀死,此效应的意义在于只需少量的肿瘤细胞转染自杀基因,就可产生广泛的杀伤作用[1]。 The research of ovarian cancer gene therapy attracts much attention, and suicide gene therapy is considered as one of the most promising strategies. It has a unique killing mechanism, that is, “bystander effect”, killing of tumor cells transfected with suicide gene Dead, and around a large number of non-transfected tumor cells were also killed, the significance of this effect is that only a small amount of tumor cells transfected with suicide genes, can produce a wide range of killing [1].