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锌(Zn)是生命体不可或缺的微量元素,对细菌和宿主同等重要。细菌体内锌离子稳态的维持依赖锌离子转运和调控体系。宿主通过限制锌离子或高锌离子中毒来控制细菌感染。为了在宿主体内生存,细菌必须表达高亲和力的锌离子转运系统,如ZnuABC,以获取足够的锌离子。由于锌与细菌大量的代谢和毒性通路密切相关,在细菌建立感染的过程中尤为重要,因此通过抑制锌离子转运系统来影响锌离子的稳态,将成为一个非常有发展前途的新型抗菌策略。
Zinc (Zn) is an indispensable trace element in life and is equally important to bacteria and host. The maintenance of zinc homeostasis in bacteria depends on zinc ion transport and regulation system. Hosts control bacterial infections by limiting zinc or zinc poisoning. To survive in the host, bacteria must express a high-affinity zinc ion transport system, such as ZnuABC, to get enough zinc ions. Because zinc is closely related to a large number of metabolic and toxic pathways of bacteria and is particularly important in the process of bacterial infection, it is a promising new antimicrobial strategy by inhibiting zinc ion transport system to affect the steady state of zinc ions.