论文部分内容阅读
Tourette综合征(TS)为起病于童年持续终生的运动和发音障碍,以前一直用氟哌啶醇及其它抗精神病药治疗,效果肯定,但此类药物常因各种副作用而中断治疗。1979年首次报道可乐亭(clonidine)治疗TS有效,并认为该药可替代抗精神病药。但报道结果不一致。本研究用可乐亭与安慰剂治疗12周,进行双盲对照试验,以此评定可乐亭治疗TS的安全性和有效性。方法:参加实验病例符合DSM-Ⅲ的TS标准,抽动秽语综合征大体量表(TSGS)分大于30,达到需临床干预标准,排除影响TS
Tourette’s syndrome (TS), a motor and speech disorder that has been implicated in childhood’s lifelong lifespan, has been previously treated with haloperidol and other antipsychotics with positive results, but such drugs are often discontinued due to various side effects. It was first reported in 1979 that clonidine was effective in the treatment of TS and considered it as an alternative to antipsychotics. However, the results reported inconsistent. In this study, a two-blind, controlled trial was conducted with cocaine booths and placebo for 12 weeks to assess the safety and efficacy of corticosteroid in the treatment of TS. Methods: Participate in the experimental cases meet the TS standard DSM-Ⅲ, Tourette Syndrome General Scale (TSGS) points greater than 30, to reach the standard of clinical intervention, excluding the impact of TS