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趋化因子(Chemokjne)是一类可诱导的,由多种细胞产生,有激活和趋化白细胞作用,分子量为7 KDa～10KDa的促炎细胞因子,它们在抗感染和免疫中有至关重要的作用。根据其前两个半胱氨酸残基的相对位置不同,将它们分为了四大类:CXC趋化因子,CC趋化因子,C趋化因子和CX3C趋化因子。相应的趋化因子受体则分为CXC趋化因子受体(CXCR),CC趋化因子受体(CCR),C趋化因子受体(CR)和CX3C趋化因子受体(CX3CR),但它们都为GPCR家族成员(一类介导趋化因子使功能性GTP-蛋白耦连的七次跨膜受体)。目前已经发现了50多种趋化因子和20多种趋化因子受体。趋化
Chemokjne is a class of inducible, proinflammatory cytokines that are produced by a wide range of cells and that have an activation and chemotaxis of leukocytes and a molecular weight of 7 KDa to 10 KDa, which are crucial in fighting infection and immunity Role. They are grouped into four broad categories based on the relative positions of the first two cysteine residues: CXC chemokines, CC chemokines, C chemokines and CX3C chemokines. The corresponding chemokine receptors were divided into CXC, CC chemokine receptor (CCR), C chemokine receptor (CR) and CX3C chemokine receptor (CX3CR) But all are members of the GPCR family (a family of seven transmembrane receptors that mediate chemokine binding of functional GTP-proteins). More than 50 chemokines and more than 20 chemokine receptors have been discovered so far. trend