Objective To explore the role of hMSH2,a novel endogenous tumor-associated protein ligand recognized by Vγ9δ2 T cells,in innate anti-cervix cancer immunity.Methods hMSH2 that expressed on the surface of cervical cancer cell line HeLa cells was blocked by specific antibody.Then the differences in their effects on Vγ9δ2T cells before and after antibody blockage were evaluated by cytotoxicity of Vγ9δ2 T cells and cytokines secretion. Objective To explore the role of hMSH2, a novel endogenous tumor-associated protein ligand recognized by Vγ9δ2 T cells, in innate anti-cervix cancer immunity. Methods hMSH2 that expressed on the surface of cervical cancer cell line HeLa cells was blocked by specific antibody. Then the differences in their effects on Vγ9δ2T cells before and after antibody blockage were evaluated by cytotoxicity of Vγ9δ2 T cells and cytokines secretion.