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目的探讨大剂量化疗治疗小儿急性淋巴细胞白血病的疗效及对生活质量的影响。方法将收治的56例经骨髓细胞形态学、免疫组织化学、融合基因、染色体确诊为急性淋巴细胞白血病患儿随机分为A组和B组,每组28例,A组患者采用HD-MTX、6-MP联合三联鞘注方案,B组采用VDLP方案,观察临床疗效和生活质量。结果 A组较B组患者总有效率明显提高,差异有统计学意义(P<0.05)。A组患者的生活质量量表评分显著高于B组,差异有统计学意义(P<0.05)。结论大剂量化疗治疗急性淋巴细胞白血病疗效显著,可有效提高患儿生活质量,远期效果显著。
Objective To investigate the effect of high-dose chemotherapy on childhood acute lymphoblastic leukemia and its impact on quality of life. Methods A total of 56 cases of children with acute lymphoblastic leukemia diagnosed as myeloid cell morphology, immunohistochemistry, fusion gene and chromosomal diagnosis were randomly divided into group A and group B, with 28 cases in each group. Patients in group A received HD-MTX, 6-MP combination triple sheath injection program, B group using VDLP program to observe the clinical efficacy and quality of life. Results The total effective rate of group A was significantly higher than that of group B, the difference was statistically significant (P <0.05). The quality of life scale in group A was significantly higher than that in group B, the difference was statistically significant (P <0.05). Conclusion High-dose chemotherapy in the treatment of acute lymphoblastic leukemia with significant effect, can effectively improve the quality of life of children with long-term effect is significant.