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目的探讨中老年教师原发性高血压(PH)伴短暂性脑缺血(TIA)患者颅内动脉狭窄的患病情况及其与慢性血管疾病危险因素的关系。方法对110例PH伴TIA中老年教师患者进行颅内动脉CT血管造影(CTA)、身高、体重、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FBS)和血尿酸(SUA)检测,将结果分为颅内动脉狭窄与非狭窄两组并进行探索性分析。结果共有67例103处颅内血管有轻度以上狭窄,其中有1处狭窄44例,2处15例,3处4例,4处3例,5处1例;狭窄程度:轻度32例,中度23例,重度8例,闭塞4例;狭窄血管:颈内动脉60例(占54.5%),椎动脉15例(占7.3%),大脑中动脉12例(占10.9%),大脑后动脉9例(占8.2%),前交通动脉9例(占8.2%),大脑前动脉3例(占2.7%)和后交通动脉3例(占2.7%),不同部位动脉狭窄发生率差异有统计学意义(χ2=151.959,P=0.000),不同部位不同性别动脉狭窄发生率差异无统计学意义(P>0.05),动脉狭窄组其体质指数(BMI)、TC、TG、FBS和SUA的平均值较非动脉狭窄组高(P均<0.01)。回归分析结果:高血压和SUA、TC、BMI、FBS与颅内血管的狭窄有协同作用(P<0.01)。结论中老年教师PH伴TIA颅内动脉狭窄患病率为55.8%,颅内动脉狭窄患者,其BMI、TC、TG、FBS和SUA的平均值较非动脉狭窄组高,SUA、TC和FBS是PH伴TIA颅内动脉狭窄的重要危险因素,高血压和SUA、TC、BMI、FBS与颅内动脉狭窄有协同作用。
Objective To investigate the prevalence of intracranial arterial stenosis and its relationship with risk factors of chronic vascular disease in middle-aged and elderly teachers with essential hypertension (PH) and transient ischemic attack (TIA). Methods One hundred and thirteen PH patients with TIA were enrolled in this study. The CT angiography (CTA), height, weight, total cholesterol (TC), triglyceride (TG), fasting blood glucose (FBS) and serum uric acid (SUA) Detection, the results were divided into two groups of intracranial stenosis and non-stenosis and exploratory analysis. Results A total of 67 cases of 103 intracranial vessels with mild to more stenosis, including 1 stenosis in 44 cases, 2 in 15 cases, 3 in 4 cases, 4 in 3 cases, 1 in 5 cases; stenosis: mild in 32 cases , Moderate in 23 cases, severe in 8 cases and occlusion in 4 cases. Stenosed vessels included 60 cases of internal carotid artery (54.5%), 15 cases of vertebral artery (7.3%), 12 cases of middle cerebral artery (10.9% 9 cases (8.2%) of the posterior arteries, 9 cases (8.2%) of the anterior communicating artery, 3 cases (2.7%) of the anterior cerebral artery and 3 cases of the posterior communicating artery (2.7%). The incidence of arterial stenosis There was no significant difference in the incidence of arterial stenosis between different genders (χ2 = 151.959, P = 0.000), BMI, TC, TG, FBS and SUA in arterial stenosis group The average value of non-arterial stenosis group was higher (P <0.01). Regression analysis results: Hypertension and SUA, TC, BMI, FBS synergies with intracranial stenosis (P <0.01). Conclusions The prevalence of intracranial arterial stenosis in middle-aged and senior-aged PH patients with TIA is 55.8%. The mean values of BMI, TC, TG, FBS and SUA in patients with intracranial arterial stenosis are higher than those in non-arterial stenosis. SUA, TC and FBS are PH with TIA intracranial arterial stenosis of an important risk factor, hypertension and SUA, TC, BMI, FBS synergies with intracranial artery stenosis.