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龙游县自1970年首次报告钩端螺旋体病至1997年共发生1369例,死亡9例,年均发病率为13.41/10万,病死率为0.66%,其中1973年为历史发病最高年份,发病率为105.09/10万,在27年期间共发生五次钩体病局部暴发流行。发病季节以8~10份为高峰,发病以农民青壮年为主,男性多于女性,本病流行形式主要为稻田型和洪水型。临床上以黄疸出血型和流感伤寒型为主。鼠类、猪是主要传染源,从鼠类、活蛙、猪肾、犬肾和牛尿等615份标本中分离到钩端螺旋体菌株6株,菌型分布主要是黄疸出血群和七日热群。鼠总密度为13.01%,黑线姬鼠为优势种。观察菌苗接种与发病的关系,无接种史者发病的危险度为接种者的4.91倍。
Longyou County reported for the first time in 1970 leptospirosis to 1997, a total of 1369 cases, 9 deaths, the average annual incidence rate of 13.41 / 100,000, the case fatality rate was 0.66%, of which 1973 was the highest incidence of history, the incidence The rate was 105.09 / 100 000 during which five outbreaks of leptospirosis took place during 27 years. Occurrence season peaked at 8 to 10, the incidence of peasant young and middle-aged, more men than women, the epidemic forms of this disease mainly paddy and flood type. Clinically, jaundice bleeding and typhoid-type influenza-based. Rodents and pigs were the main sources of infection. Six strains of Leptospira were isolated from 615 specimens of rodents, live frogs, pig kidney, canine kidney and cow urine. The distribution of strains was mainly jaundice hemorrhage and seven-day fever group . The total density of rats was 13.01%. Apodemus agrarius was the dominant species. Vaccination and observation of the relationship between the incidence of vaccination, vaccination history of the incidence of the risk of vaccination 4.91 times.