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目的:探讨临床型、亚临床型精索静脉曲张不育症患者性激素水平的变化以及对精液参数的影响。方法:选择临床型精索静脉曲张不育症患者(A组)、亚临床型精索静脉曲张不育症患者(B组)、正常生育者(C组)各30例,采用酶联免疫定量测定法(ELISA)测定其外周血性激素水平,用计算机辅助精液分析仪测定精子密度、活动精子、前向运动精子、快速前向运动精子以及畸形精子百分率。结果:①A组与C组比较,FSH、LH明显升高,而T明显下降(P<0.05),B组与C组,以及A组与B组之间FSH、LH、T差异无统计学意义(P>0.05)。②A组与B组与C组比较,精子密度、活动精子、前向运动精子、快速前向运动精子百分率均有明显下降,畸形精子百分率升高(P<0.05),同时A组与B组比较,差异也有显著性(P<0.05)。结论:精索静脉曲张程度越重,其对外周血性激素水平及精液参数影响越大。早期发现亚临床型精索静脉曲张对治疗男性不育症有指导意义。
Objective: To investigate the changes of sex hormones in patients with clinical and subclinical varicocele as well as their effects on semen parameters. Methods: A total of 30 patients with clinical varicocele infertility (group A), 30 patients with subclinical varicocele infertility (group B) and 30 normal births (group C) were enrolled in this study. Peripheral blood hormone levels were measured by ELISA. Sperm density, motile sperm, motile spermatozoa, pre-motile spermatozoa and percentage of abnormal spermatozoa were measured by computer-assisted semen analyzer. Results: ①Compared with C group, FSH and LH increased significantly, while T decreased significantly (P <0.05). There was no significant difference in FSH, LH and T between B group and C group, A group and B group (P> 0.05). (2) Compared with group C, sperm density, sperm motility, motile spermatozoa and the percentage of fast forward motile sperm in group A, group B and group C decreased significantly (P <0.05), while group A and group B compared with group C , The difference was also significant (P <0.05). Conclusion: The more severe varicocele, the greater its influence on serum levels of hormones and semen parameters. Early detection of subclinical varicocele in the treatment of male infertility is instructive.