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目的 探讨系统性红斑狼疮(SLE)患者血清中IL-2、IL-10的表达与双链DNA(ds-DNA)的关系。方法 用酶联免疫吸附试验(ELISA)检测了22例SLE患者血清中的白细胞介素2(IL-2)、IL-10和抗ds-DNA抗体水平。结果 SLE患者血清中IL-10和IL-10/IL-2比值均与抗ds-DNA抗体呈现较好的正相关性,IL-2与抗ds-DNA抗体呈现低度负相关性或不相关。结论 血清中IL-10、IL-10/IL-2比值与抗ds-DNA抗体的相关性可作为SLE患者病情的诊断、监测和疗效观察的指标。
Objective To investigate the relationship between the expression of IL-2 and IL-10 in serum of patients with systemic lupus erythematosus (SLE) and double-stranded DNA (ds-DNA). Methods Serum levels of interleukin 2 (IL-2), IL-10 and anti-dsDNA antibody in 22 SLE patients were detected by enzyme linked immunosorbent assay (ELISA). Results The serum levels of IL-10 and IL-10 / IL-2 in SLE patients showed a positive correlation with the anti-dsDNA antibody, and IL-2 and anti-dsDNA antibody showed a low negative correlation or not . Conclusion The correlation between serum IL-10, IL-10 / IL-2 ratio and anti-dsDNA antibody may be used as an indicator of the diagnosis, monitoring and curative effect of SLE patients.