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Objective:To explore the correlation between the distribution of 14bp polymorphism in exon 8 of human leukocyte antigen-G (HLA-G) gene in Hainan Li nationality and susceptibility to severe preeclampsia.Methods: 100 cases of severe preeclampsia inpatients (experimental group) admitted to our hospital from June 2018 to September 2019 were selected. Among them, 50 were Li and 50 were Han, and 100 were admitted to our hospital during the same period Normal pregnant women were the control group, including 50 cases of Li nationality and 50 cases of Han nationality. Venous blood was collected to detect the 14bp polymorphism in HLA-G gene exon 8, and the correlation between the 14bp polymorphism in HLA-G gene exon 8 and susceptibility to severe preeclampsia was analyzed.Results: There was a statistically significant difference in the 14-bp genotyping and allele frequency in HLA-G exon 8 of the Li ethnic group in the control group and the experimental group (P <0.05). The SBP and DBP of the Li 14-14 / 14bp typing, + 14bp / -14bp typing, and allele -14bp typing were lower in the experimental group than in the Han group in the experimental group (P <0.05), and the SBP of + 14bp / -14bp typing DBP was higher than that of Han patients in the experimental group (P <0.05). Binary Logistic Regression Analysis + 14bp / -14bp was associated with the incidence of severe preeclampsia in Li women in Hainan region (P <0.05). The -14bp / -14bp classification was a protective factor for severe preeclampsia in Li women in Hainan region (P<0.05).Conclusion: The HLA-G gene exon 8 carrying a 14bp deletion polymorphism in the Hainan Li nationality is associated with preeclampsia susceptibility and progression.