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近来发现静脉注射用硝酸甘油(NTG),可降低急性心功能不全所致的缺血性损害程度。因医院药房制备的静脉用 NTG 注射液已取代供舌下含服的传统商品,然其制品尚存在药效及稳定性问题。本文作者将 NTG 溶于5%葡萄糖溶液(GS)后装入玻璃瓶或塑料袋中,置室温(25±1℃)、室内曝光、室内避光及冷藏等条件下贮存,分别干配制后的不同时间取样,测定药物消失速度。实验结果表明:用玻璃瓶或塑料袋装 NTG 的消失率无明显区别,且在避光及冷藏条件下并不能明显提高其保存效果,无论用
Recently found that intravenous nitroglycerin (NTG), can reduce the degree of ischemic damage caused by acute cardiac insufficiency. The intravenous NTG injection prepared by the hospital pharmacy has replaced the traditional products for oral sublingual administration, but its products still have problems of efficacy and stability. In this study, NTG was dissolved in 5% glucose solution (GS) and then stored in glass bottles or plastic bags, stored at room temperature (25 ± 1 ℃), exposed to room light, protected from light and cold in the room, Sampling at different times to determine the rate of drug disappearance. The experimental results show that there is no significant difference in the disappearance rate of NTG in glass bottles or plastic bags, and the storage effect of NTG can not be obviously improved under the conditions of light and cold storage.