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目的:通过检测血小板参数MPV、D-二聚体及血清C-反应蛋白(CRP)水平,探讨其对溃疡性结肠炎(UC)的活动性的评价。方法:分别采用免疫扩散比浊法和自动血细胞分析系统分析及免疫比浊法检测65例活动期和36例缓解期溃疡性结肠炎患者及53位健康对照者的血小板参数MPV、D-二聚体及血清C-反应蛋白的水平及其间的关系,比较临床严重程度对MPV及D-二聚体及CRP的影响。结果:(1)、活动期溃疡性结肠炎患者平均血小板体积(MPV)明显低于缓解期患者及正常对照组(P<0.01),血清CRP及D-二聚体与缓解期患者及正常对照组相比明显增高(P<0.01),缓解期患者MPV较正常对照组也降低(P<0.05),缓解期CRP水平与对照组比较,差别有统计学意义(P<0.05),而D-二聚体水平与对照组比较,差别无统计学意义(P>0.05),(2)、重型UC患者MPV、CRP及D-二聚体水平与轻中型患者比较,差别有统计学意义(P<0.05)。结论:MPV、CRP及D-二聚体水平可作为溃疡性结肠炎(UC)的活动性的评定指标。
OBJECTIVE: To evaluate the activity of platelet parameters MPV, D-dimer and serum C-reactive protein (CRP) in patients with ulcerative colitis (UC). Methods: The platelet parameters MPV, D-dimer of 65 patients with active stage and 36 patients with remission stage ulcerative colitis and 53 healthy controls were detected by immune diffusion turbidimetric assay, automatic hematology analysis and immunoturbidimetry, respectively Body and serum C-reactive protein levels and the relationship between the severity of MPV and D-dimer and CRP. Results: (1) The mean platelet volume (MPV) of patients with active ulcerative colitis was significantly lower than that of patients with remission and normal control (P <0.01). Serum CRP, D-dimer and remission patients and normal controls (P <0.01). The MPV in remission group was also lower than that in normal control group (P <0.05). The CRP level in remission group was significantly lower than that in control group (P <0.05) Dimer level compared with the control group, the difference was not statistically significant (P> 0.05), (2), severe UC patients with MPV, CRP and D-dimer levels compared with light and medium patients, the difference was statistically significant (P <0.05). CONCLUSIONS: The levels of MPV, CRP and D-dimer can be used as a measure of activity in ulcerative colitis (UC).