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胃癌患者的预后与侵袭和转移有关。有证据表明 实体瘤侵袭和转移需要肿瘤相关蛋白酶的作用,该酶能促进肿瘤周围基质及基底膜的溶解。丝氨酸蛋白酶尿激酶类纤维蛋白溶酶原激活物(uPA)及其抑制物——纤维蛋白溶酶原激活物抑制因子-1(PA1-1)在这一过程中起重要作用。近来报道,乳腺癌及结肠癌蛋白水解酶表达水平升高,可能与肿瘤侵袭及预后不良有关。因此,作
The prognosis of gastric cancer patients is related to invasion and metastasis. There is evidence that the invasion and metastasis of solid tumors require the action of tumor-associated proteases that promote the dissolution of the matrix and basement membrane surrounding the tumor. The serine protease urokinase-type plasminogen activator (uPA) and its inhibitor, plasminogen activator inhibitor-1 (PA1-1), play an important role in this process. Recently, it has been reported that the elevated expression levels of proteolytic enzymes in breast cancer and colon cancer may be related to tumor invasion and poor prognosis. Therefore, for