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目的:观察草酸铂(L-OHP)联合新型重组人肿瘤坏死因子(NrhTNF)腹腔内注射治疗恶性腹水的临床疗效、不良反应、对生存质量的影响。方法:20例晚期胃肠道肿瘤所致恶性腹水患者,(L-OHP)联合NrhTNF腹腔内注射,每周1次,连续2周。结果:20例患者无CR,PR55%(11/20),SD35%(7/20)。主要不良反应为腹痛、发热、恶心,均较轻微。生活质量改善80%(16/20)。结论:(L-OHP)联合NrhTNF腹腔内注射治疗晚期胃肠道癌性腹水效果显著,不良反应轻微,可明显改善患者生存质量。
Objective: To observe the effect of L-OHP combined with intraperitoneal injection of recombinant human tumor necrosis factor (NrhTNF) on the treatment of malignant ascites due to adverse reactions and adverse effects on the quality of life. Methods: Twenty patients with malignant ascites caused by advanced gastrointestinal cancer were injected intraperitoneally with L-OHP and NrhTNF once a week for 2 weeks. Results: There were no CR, PR55% (11/20) and SD35% (7/20) in 20 patients. The main adverse reactions were abdominal pain, fever, nausea, are minor. Improve quality of life by 80% (16/20). Conclusion: The combination of (L-OHP) and NrhTNF intraperitoneal injection is effective in treatment of advanced gastrointestinal cancerous ascites with slight adverse reactions, which can significantly improve the quality of life of patients.