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原始的多能造血干细胞可形成各种血液成分,包括粒细胞、红细胞和免疫细胞。干细胞常被称为CFU-S,即脾集落形成单位。多能干细胞定向发育的过程尚不大清楚。看来在生理条件下,大多数血细胞生成的调节可能发生在定向干细胞阶段。过去几年内已逐渐明确,多种多样的细胞相互作用可影响由干细胞前身到成熟血细胞的形成过程。确定这些相互作用的特点有待于造血细胞体外培养的方法学的改进。其中,特别重要的是已发展出一种半固体凝胶培养系统,适用于单核细胞干细胞和粒细
The primitive pluripotent hematopoietic stem cells form a variety of blood components, including granulocytes, erythrocytes, and immune cells. Stem cells are often referred to as CFU-S, the spleen colony-forming unit. The process of directional development of pluripotent stem cells is not yet clear. It appears that under physiological conditions most of the regulation of hematopoiesis may occur in the direction of the stem cell. Over the past few years has gradually become clear that a wide range of cell interactions can affect the process from stem cell precursors to mature blood cells. Determining the characteristics of these interactions needs to be improved on the methodology of in vitro culture of hematopoietic cells. Among them, it is particularly important that a semi-solid gel culture system has been developed that is suitable for monocyte-derived stem cells and fine