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多发性淋巴瘤性息肉病(MLP)是原发性非Hodgkin胃肠道B细胞瘤中较少见的一型,其特征是沿胃肠道呈现多发的淋巴瘤性息肉。 对1984年1月至1995年12月间350例原发性消化道淋巴瘤的病人中按Kiel标准诊断的31例MLP进行了前瞻性研究。患者平均年龄55岁,男性多于女性(2.6:1)。主要临床表现为:腹痛、腹泻、便血、体重减轻和乏力。91%的病人肠系膜淋巴结受侵,肠外最易侵及骨髓,其次为外周淋巴结、咽部淋巴环和肝脏,但未见有肺和纵隔病灶。内镜下可见胃肠道一段或多段有2毫米至数厘米大小的典型小结节或息肉样肿瘤。胃粘膜脑回样皱襞为本病的特征,小肠造影可见腔内无数圆形缺损,有时肿瘤位于回肠末端。组织学特征为小到中等大小同一种分裂细胞组成,核不规则,不明显的小核仁,少胞浆。
Multiple lymphoma polyposis (MLP) is a less common form of primary non-Hodgkin gastrointestinal B-cell neoplasms and is characterized by multiple lymphoma polyps along the gastrointestinal tract. A prospective study of 31 MLPs diagnosed according to the Kiel criteria in 350 patients with primary gastrointestinal lymphoma between January 1984 and December 1995 was performed. The average age of the patients was 55 years and more men than women (2.6:1). The main clinical manifestations are: abdominal pain, diarrhea, hematochezia, weight loss, and fatigue. 91% of patients had mesenteric lymph nodes invaded, the most invasive bone marrow was extraintestinal, followed by peripheral lymph nodes, pharyngeal lymphatic rings, and liver, but no lung and mediastinal lesions were seen. One or more segments of the gastrointestinal tract, typically small nodules or polypoid tumors of 2 mm to several cm in size, are seen endoscopically. Gastric brain reflexology is a feature of the disease. Intestinal angiography shows numerous round defects in the lumen, and sometimes the tumor is located at the end of the ileum. Histological features consist of small to medium-sized cells of the same division, nuclear irregularities, insignificant small nucleoli, and less cytoplasm.