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目的探讨眼眶髓外浆细胞瘤(EMP)的临床特点、诊断及治疗方法。设计回顾性病例系列。研究对象EMP患者4例。方法回顾分析我院2003年7月～2005年12月间收治的4例EMP患者的资料,分析其临床特点、病理诊断分型。4例患者均行手术加辅助放射治疗。主要指标EMP的临床特点、病理诊断及治疗方法。结果临床主要表现为眼球突出和局部肿物及其引起的相应症状。4例均行手术切除肿物,病理诊断为髓外浆细胞瘤。免疫组化检测,2例κ型,2例λ型,3例浆细胞抗体阳性。4例尿本周蛋白均为阴性。2例骨髓穿刺均未见异常。4例胸部经X线检查均正常。术后平均随访24个月,均无局部复发、远处转移。结论EMP的诊断主要依靠临床表现和病理并经系统检查除外多发性骨髓瘤。手术和放射治疗是EMP的主要治疗手段。
Objective To investigate the clinical features, diagnosis and treatment of orbital pulp plasmacytoma (EMP). Design retrospective case series. Study of EMP patients in 4 cases. Methods The data of 4 patients with EMP admitted from July 2003 to December 2005 in our hospital were retrospectively analyzed. Their clinical features and pathological diagnosis were analyzed. 4 patients underwent surgery plus adjuvant radiotherapy. The main indicators EMP clinical features, pathological diagnosis and treatment. Results The main clinical manifestations of prominent and local eyeballs caused by the corresponding symptoms. 4 cases underwent surgical resection of the tumor, pathological diagnosis of extramedullary plasmacytoma. Immunohistochemical detection, 2 cases of κ, 2 cases of λ, 3 cases of plasma cell antibody positive. 4 cases of urine week protein were negative. Two cases of bone marrow biopsy were normal. 4 cases of chest X-ray examination were normal. After an average follow-up of 24 months, no local recurrence and distant metastasis. Conclusions The diagnosis of EMP mainly depends on the clinical manifestations and pathology and excludes multiple myeloma through systematic examination. Surgery and radiation therapy are the main treatments of EMP.