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作者在非洲遇到一种具有血清HBsAg阳性、无抗-HBc特征的人类新型病毒性感染。在因疫苗接种或自然HBV感染而抗-HBs阳性的儿童中已发现了这种病毒感染。这种新型的HBsAg阳性,而无抗-HBc的特征,并在HBsAg消失后,抗-HBc或抗-HBs都不能检测到。此外,受感染的病人,检测不到HBeA。在这种HBsAg阳性血清中,观察到直径为45～60nm,氯化铯梯度超速离心密度为1.25～1.27的病毒颗粒和一些为22～30nm球形颗粒。来自HBsAg阳性、抗-HBc阴性感染个体中的15份血清标本,仅1例微弱地检测到HBsAg DNA互补序列。这可能是由于血清中病毒浓度太低以及部分核酸与HBV同源的缘故。因该病毒与
In Africa, the authors have encountered a new type of human viral infection that has a serum HBsAg-positive, anti-HBc-free character. This virus infection has been found in children who are anti-HBs positive due to vaccination or natural HBV infection. This new type of HBsAg is positive with no anti-HBc characteristics and can not be detected by anti-HBc or anti-HBs after the disappearance of HBsAg. In addition, HBeA was undetectable in infected patients. In this HBsAg positive serum, virus particles with a diameter of 45-60 nm, a cesium chloride gradient ultracentrifugation density of 1.25-1.27 and some spherical particles of 22-30 nm were observed. In 15 serum samples from HBsAg-positive, anti-HBc-negative individuals, only 1 patient weakly detected the HBsAg DNA complement. This may be due to the virus concentration in the serum is too low and part of the nucleic acid homologous to HBV sake. Because of the virus and