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目的观察与分析口腔鳞癌癌旁上皮的病理变化及意义。方法运用图像分析技术对３４例口腔鳞癌标本的癌旁上皮和其它不同区域作形态定量研究，分析其上皮厚度、上皮钉长度、基底细胞和棘细胞面积及核浆比。结果①邻近的癌旁上皮其厚度、上皮钉长度与远处及正常区域的指标相比显著增加；②基底细胞面积及棘细胞核浆比依肿瘤边缘、邻近的癌旁上皮、远处癌旁上皮至正常区域的顺序逐渐减小。结论口腔鳞癌癌旁上具有高度恶变的危险性，形态定量研究对于探讨其癌变发生规律具有重要价值。
Objective To observe and analyze the pathological changes and clinical significance of para-carcinoma adjacent to oral squamous cell carcinoma. Methods 34 cases of squamous cell carcinoma of the oral squamous cell carcinoma and other different regions were quantitatively studied by using image analysis technique. The epithelial thickness, the length of epithelial nails, the area of basal cells and spine cells and the ratio of nucleus to plasma were analyzed. Results ① The adjacent paracancerous epithelium had a significant increase in the thickness and length of the nails compared with the distant and normal regions. ② The area of basal cell and the ratio of nucleus pulposus to tumor adjacent to the tumor, adjacent paracancerous epithelium, distant paraneoplastic epithelium The order to the normal area gradually decreases. Conclusion Oral squamous cell carcinoma adjacent to the high risk of malignant transformation, morphological quantitative study of its carcinogenesis has important value.