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目的:优选栀子柏皮汤半仿生提取药材组合方式,为栀子柏皮汤提取工艺提供依据。方法:将方中方药按“君(A),臣(B),佐(C),使(D)”进行组合排列,共5种,用半仿生提取方法进行提取;以相对分子质量≤1 000 Da提取物、栀子苷、盐酸小檗碱、甘草次酸、总生物碱为指标,将各指标测得值标准化处理,经加权求和后得到综合评判值进行比较,大者为优。结果:5个指标综合评判值排序依次为B+AC>A+B+C>C+AB>ABC>A+BC,以B+AC(关黄柏单煎,栀子、甘草合煎)最大。结论:栀子柏皮汤半仿生提取方法以关黄柏单煎,栀子、甘草合煎,最后合并提取液为最佳。
OBJECTIVE: To optimize the combination of semi-bionic extraction of gardenia baiyi soup and provide the basis for the extraction of gardenia bai bang decoction. Methods: The prescriptions of Chinese herbs were arranged in a combinatorial order of “A, B, C and D”, and were extracted by semi-bionic extraction. The relative molecular mass ≤1 000 Da extract, geniposide, berberine hydrochloride, glycyrrhetinic acid, total alkaloids as indicators, the indicators measured values standardized treatment, the weighted sum obtained after the comprehensive evaluation of the value of the larger excellent. Results: The order of comprehensive evaluation of the five indicators was B + AC> A + B + C> C + AB> ABC> A + BC, with B + AC being the largest. CONCLUSION: The semi-bionic extraction method of Gardenia Bibi Tang is best for the treatment of Guanbai Pingshan, Gardenia jasminoides, and Licorice combined with the decoction.