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目的 :以壳聚糖为增稠剂及增效剂 ,研制盐酸洛美沙星壳聚糖滴眼液 ,以增强其疗效 ,减少给药次数。方法 :经筛选选定本品处方及制备方法 ,对其性状、粘度、含量、稳定性等质量进行检测 ,并对其临床疗效作了初步考察。结果 :壳聚糖的加入不影响主药的理化性质 ,对其含量测定亦无干扰。临床疗效观察本品对眼无刺激 ,痊愈率、总有效率及细菌转阴率与盐酸洛美沙星滴眼液无显著差异 (P >0 .0 5 ) ,但平均治愈天数明显缩短 (P <0 .0 5 ) ,给药次数亦减半。结论 :本品制备简单 ,质量稳定 ,疗效确切 ,同时表明壳聚糖是一种很有应用价值的新型眼用增稠剂和增效剂
Objective: To chitosan thickener and synergist, the development of lomefloxacin hydrochloride chitosan eye drops to enhance its efficacy and reduce the number of administration. Methods: The prescriptions and preparation methods were selected by screening. The quality, viscosity, content and stability of the products were tested, and the clinical efficacy was preliminarily investigated. Results: The addition of chitosan did not affect the physicochemical properties of the main drug, its content determination also without interference. Clinical Observations This product is non-irritating to the eye, the cure rate, the total effective rate and the negative rate of bacteria and lomefacil hydrochloride eye drops no significant difference (P> 0.05), but the average number of days to cure was significantly shorter (P < 0. 0 5), the number of dosing is also halved. Conclusion: The preparation of this product is simple, stable quality, curative effect is exact, at the same time shows that chitosan is a kind of new ophthalmic thickener and synergist