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在回顾传统的有阈和线性无阈的剂量-反应关系的基础上,分析此类该模型被毒理学领域认同的主要原因和其在预测低剂量效应中的缺陷,进而提出了高剂量接触呈现抑制效应,而低剂量却呈现促进或刺激作用这一全面的激效兴奋性剂量-反应关系,弥补了现有模型的不足,并充分论证这种激效性剂量-反应关系在不同种属、接触因素和生物学终点中的普遍性,并探讨了不同物质的激效兴奋作用的可能机制以及激效兴奋模型的三大优点,最后提出了激效模型谋求广泛接受的现实困难和发展趋势。
Based on the review of the traditional threshold-free and linear-threshold dose-response relationships, the main reason for this model identification in the toxicology field and its shortcomings in predicting low-dose effects are analyzed. Then the high-dose exposure is presented Inhibitory effect, while the low-dose showed a stimulating or stimulating effect of the full excitatory dose-response relationship to make up for the deficiencies of the existing model and fully demonstrated that the dose-response relationship of this exciting effect in different species, Contact factors and endpoints in biology, explores the possible mechanisms of excitatory effects of different substances and the three major advantages of excitatory stimulus models, and finally puts forward the practical difficulties and development trends of stimulating models for widespread acceptance.