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目的 :通过体外药敏试验 ,研究胰腺癌细胞对化疗药物的敏感性 ;筛选敏感的化疗药物 ,指导临床化疗方案的制定 ,并讨论胰腺癌化疗个体化方案的意义。方法 :用MTT比色法检测 40例原代培养的胰腺癌细胞对氨甲蝶呤、5 氟脲嘧啶、丝裂霉素、长春地辛、羟基喜树碱、依托泊甙、顺铂、表阿霉素、吡柔比星和健择等 1 0种药物的敏感性。结果 :以上 1 0种药物对 40例原代胰腺癌细胞生长抑制率分别为 2 8 6± 1 7 9%、41 3± 2 0 7%、45 4± 2 3 0 %、38 4± 2 4 6 %、37 3± 2 1 5 %、39 5± 2 0 7%、37 0± 1 9 0 %、33 7± 2 1 0 %、38 4± 1 8.3%和 42 8± 1 9.5 % ,共有 33例 (83 % )筛选到了抑制率 >60 %的药物。结论 :体外培养的胰腺癌细胞对 1 0种化疗药物的敏感性较差 ;不同的胰腺癌细胞对不同的药物敏感。通过体外药敏试验筛选敏感药物行个体化化疗是提高胰腺癌化疗效果的一条有希望的途径
OBJECTIVE: To study the sensitivity of pancreatic cancer cells to chemotherapeutic drugs in vitro susceptibility testing, to screen sensitive chemotherapeutic drugs, to guide the formulation of clinical chemotherapy regimens, and to discuss the significance of individualized chemotherapy regimens for pancreatic cancer. Methods: MTT assay was used to detect the expression of methotrexate, 5-fluorouracil, mitomycin, vindesin, hydroxycamptothecin, etoposide and cisplatin in 40 primary cultured pancreatic cancer cells Doxorubicin, pirarubicin and gemcitabine and other 10 kinds of drug sensitivity. Results: The inhibitory rates of the above 10 kinds of drugs on 40 primary pancreatic cancer cells were respectively 2 8 6 ± 1 7 9%, 41 3 ± 2 0 7%, 45 4 ± 2 30%, 38 4 ± 2 4 6%, 37 3 ± 2 1 5%, 39 5 ± 2 0 7%, 37 0 ± 1 90%, 33 7 ± 2 1 0%, 38 4 ± 1 8.3% and 42 8 ± 1 9.5% Thirty-three patients (83%) screened for drugs with an inhibition rate> 60%. CONCLUSION: Pancreatic cancer cells cultured in vitro are less sensitive to 10 chemotherapeutic drugs; different pancreatic cancer cells are sensitive to different drugs. Screening Sensitive Drugs by In Vitro Sensitivity Tests Individualized chemotherapy is a promising way to improve the efficacy of chemotherapy in pancreatic cancer