Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：daqscx

【摘要】

：

Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids a

【作者】

：

Li Jun Yan Quan Zhong Liu Xue

【机构】

：

Laboratory of Applied Chemistry and Pollution Control Technology

【出处】

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中国化学快报（英文版）

【发表日期】

：

2004年期

【关键词】

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Michael addition Thiottrea Enantioselectivities Nitroalkene and malonate

【基金项目】

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Key Project of the Education Department of Sichuan Province;Sichuan Provincial Science Foundation for Outstanding Youth;国家自然科学基金

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Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee).

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Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes

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