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双氯芬酸钾(diclofenac potassium)是一种非甾体类抗炎药,可抑制花生四烯酸代谢过程中的环氧化酶和脂氧化酶的活性,减少前列腺素和白三烯的合成,达到抗炎止痛的目的。因而对创伤、扭伤以及相关的中,重度疼痛和炎症有很好的疗效。 本项试验主要对双氯芬酸钾片(湖北省医药工业研究所研制)治疗急性疼痛和抗炎的临床有效性和耐受性进行评价。 1 试验设计 1.1 采用随机双盲安慰剂对照临床试验,观察妇产科阴道侧切术后或剖宫产术后(60例)以及外科中等手术后(60例)疼痛的缓解度及安全性。
Diclofenac potassium is a non-steroidal anti-inflammatory drug that inhibits the activity of cyclooxygenase and lipoxygenase in the metabolism of arachidonic acid, reduces the synthesis of prostaglandins and leukotrienes, The purpose of inflammation pain. Thus has a good effect on trauma, sprains and related moderate to severe pain and inflammation. This trial mainly evaluated the clinical efficacy and tolerability of diclofenac potassium tablets (developed by Hubei Institute of Pharmaceutical Industry) in the treatment of acute pain and anti-inflammatory. A trial design 1.1 randomized double-blind placebo-controlled clinical trials to observe the obstetrics and gynecology vaginal cesarean section or after cesarean section (60 cases) and surgical moderate surgery (60 cases) pain relief and safety.