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目的:研究益肺降纤方抗实验性大鼠矽肺纤维化的作用。方法:将40只大鼠随机分为正常组、模型组、低剂量组、高剂量组。用非暴露式气管内注入法造模后,于15、30、60天处死动物,测定的动物肺系数,肺组织病理变化及肺组织羟脯氨酸(HYP)含量。结果:低剂量组、高剂量组与模型组比较,肺系数明显降低(P<0.05),病理肺泡炎及肺纤维化明显减轻。肺组织HYP含量明显降低(P<0.05)。结论:益肺降纤方低剂量组、高剂量组均可在不同程度上改善实验性大鼠矽肺纤维化,其中以高剂量组为优。
Objective: To study the effect of Yifeijiangxian decoction on experimental pulmonary fibrosis in rats. Methods: Forty rats were randomly divided into normal group, model group, low dose group and high dose group. After non-exposed intratracheal instillation, the animals were sacrificed at 15, 30, and 60 days. Animal lung coefficient, pathological changes in lung tissue, and hydroxyproline (HYP) content in lung tissue were measured. Results: Compared with the model group, the lung coefficient was significantly lower in the low-dose group and the high-dose group (P<0.05). Pathological alveolitis and pulmonary fibrosis were significantly reduced. The HYP content in lung tissue was significantly decreased (P<0.05). Conclusion: The low-dose group and high-dose group of Yifeijiangxianfang can improve experimental pulmonary fibrosis in different degrees, and the high-dose group is superior.