大量证据表明，脊髓背角的NMDA受体的激活在长时程痛反应中起着关键作用，还有研究表明脊髓背角广动力域（WDR）神经元在长时程持续性病反应中起着重要的中介作用。NMDA受体在长时程持续性痛反应中的中枢作用已为人们所认识，但其在周围伤害性感受器处是否也有作用则尚不甚清楚 There is ample evidence that the activation of NMDA receptors in the dorsal horn of the spinal cord plays a key role in the long-term pain response and that studies have shown that the wide dynamic range (WDR) neurons in the spinal dorsal horn function as long-term persistent disease Important intermediary role. The central role of NMDA receptors in long-term sustained pain response has been well recognized, but its role in peripheral nociceptors is not yet known