论文部分内容阅读
诺如病毒是目前全球流行性腹泻的首要病原,具有丰富的遗传多样性,其中GⅡ.4型作为主要流行基因型,二十多年来通过自身变异持续感染着人类。近年来,随着病毒受体的发现以及对免疫特异性的理解,有关诺如病毒进化机制的研究得到了不断的深入,有假说提出,结合受体的转换与抗原位点的漂移是GⅡ.4型病毒进化的主要因素。同时,作为RNA病毒,高变异率及有限的基因组变异空间也决定了诺如病毒的进化方向。
Norovirus is currently the leading cause of global epidemic diarrhea, with rich genetic diversity, of which GⅡ.4 type as the main epidemic genotypes, over 20 years by their own mutation continues to infect humans. In recent years, with the discovery of the virus receptor and the understanding of the immunospecificity, the research on the evolution mechanism of Norovirus has been further studied. According to the hypothesis, the combination of receptor conversion and antigenic site drift is GII. Type 4 virus evolution of the main factors. At the same time, as RNA viruses, the high mutation rate and the limited space for genomic variation also determine the evolutionary direction of Norovirus.