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浓度为80μg/L的12-0-四葵酰基佛波-13-乙酸酯(12-0-tetradecanoylphorbol-13-acetate,TPA)被注射于20期的鸡胚眼内。24h后检测晶状体的大小和晶状体纤维数。结果实验组明显大于对照组。用同样方法,注射TPAI2h后,再注射浓度为(10(-5)mol/L)的视黄酸(retinoicacid,RA),12h后检测晶状体大小及晶状体纤维数。实验组与对照组已不存在明显的差别。实验结果表明,TPA可引起原位晶状体的过度生长;而RA则可消除TPA的这种促生长作用。TPA的促生长作用可能是由于抑制了缝隙连接通讯;而RA对TPA影响的消除则可能是使这种通讯功能恢复到正常水平。
12-0-tetradecanoylphorbol-13-acetate (TPA) at a concentration of 80 μg / L was injected into the 20th stage chick embryo eye. After 24 hours the size of the lens and the number of lens fibers were examined. Results experimental group was significantly larger than the control group. In the same way, TPA was injected for 2 hours, then injected with retinoic acid (RA) at a concentration of (10 (-5) mol / L), and the size of the lens and the number of the lens fibers were measured after 12 hours. There is no significant difference between the experimental group and the control group. Experimental results show that, TPA can cause over-growth of lens in situ; while RA can eliminate TPA this growth-promoting effect. The promoting effect of TPA may be due to the inhibition of gap junctional communication; and the elimination of the influence of RA on TPA may be to make this communication function returned to normal levels.