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目的观察扩张型心肌病患者应用阿托伐他汀治疗前、后血清C反应蛋白(C-reactive protein,CRP)、血脂及血管内皮舒张功能的变化。方法扩张型心肌病患者64例随机分为观察组与对照组各32例,对照组给予强心、利尿、血管紧张素转换酶抑制剂等常规治疗,观察组在对照组治疗基础上给予阿托伐他汀10mg/次,1次/d,口服,2组疗程均为12个月。分别于治疗前,治疗后3,12个月检测2组CRP、低密度脂蛋白(low density lipoprotein,LDL)、总胆固醇(total cholesterol,TC)水平,并比较2组血管内皮舒张功能(vascular endothelial dilatation function,VEDF)与左心室射血分数(left ventricular ejection fraction,LVEF)。结果观察组治疗后3,12个月CRP,LDL及TC水平均较治疗前降低(P<0.05),LVEF与VEDF较治疗前增高(P<0.05);对照组治疗后12个月CRP及LVEF与治疗前比较差异有统计学意义(P<0.05);2组治疗后各指标水平比较差异有统计学意义(P<0.05);观察组LVEF与血清CRP,TC及LDL呈负相关(P<0.05),与VEDF呈正相关(P<0.05)。结论阿托伐他汀可降低扩张型心肌病患者血清CRP及血脂,改善其左心室功能、内皮血管舒张功能。
Objective To observe the changes of serum C-reactive protein (CRP), blood lipid and vasodilatation in patients with dilated cardiomyopathy before and after treatment with atorvastatin. Methods Sixty-four patients with dilated cardiomyopathy were randomly divided into observation group (32 cases) and control group (32 cases). The control group was given conventional therapy such as cardiotomy, diuretic and angiotensin converting enzyme inhibitor. The observation group was given atropine Statin 10mg / time, 1 time / d, orally, two groups of treatment were 12 months. Two groups of CRP, LDL and total cholesterol (TC) were measured before treatment and 3 and 12 months after treatment. The vascular endothelial relaxation (vascular endothelial growth factor) dilatation function, VEDF and left ventricular ejection fraction (LVEF). Results The levels of CRP, LDL and TC in observation group were lower than those before treatment (P <0.05), LVEF and VEDF were higher than those before treatment (P <0.05), CRP and LVEF in control group at 12 months (P <0.05). There was significant difference between the two groups after treatment (P <0.05). There was a negative correlation between LVEF and serum CRP, TC and LDL in the observation group (P < 0.05), which was positively correlated with VEDF (P <0.05). Conclusion Atorvastatin can reduce the serum levels of CRP and lipids in patients with dilated cardiomyopathy and improve its left ventricular function and endothelial vasodilation.