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长期以来循环胆固醇增高被认为与冠心病相关,现在认为与阿尔茨海默病(Alzheimer’s disease,AD)也有关联。雌激素是一种神经保护剂,为了证明胆固醇促进APP mRNA表达和雌激素的抑制作用及其与AD的关系,我们测定了接受胆固醇和/或雌激素兔血清脂质,显示了其APP mRNA和Aβ表达。与先前报道相似,胆固醇饮食增高血清TC,TG,LDL-C和HDL-C。雌激素可逆转胆固醇饮食诱导的血清TC,TG和LDL-C增高,但降HDL-C作用不明显。高胆固醇饮食去卵巢兔APP mRNA过度表达。高胆固醇饮食同时补充雌激素去卵巢兔与正常兔间无显著差异。高胆固醇去卵巢兔Aβ刚果红染色阳性。我们的结果提示,补充雌激素降低胆固醇可能有效地预防AD。
Long-term elevated circulating cholesterol is thought to be associated with coronary heart disease and is now thought to be associated with Alzheimer’s disease (AD). Estrogen is a neuroprotective agent. To demonstrate that cholesterol promotes APP mRNA expression and estrogen inhibition and its association with AD, we measured serum lipids in cholesterol and / or estrogen-rabbit rabbits and showed that their APP mRNA and Aβ expression. Similar to previous reports, the cholesterol diet increased serum TC, TG, LDL-C, and HDL-C. Estrogen can reverse cholesterol diet-induced serum TC, TG and LDL-C increased, but the role of HDL-C is not obvious. Hypercholesterolemic diet overexpression of APP mRNA in ovariectomized rabbits. High cholesterol diet supplemented with estrogen ovariectomized rabbits and normal rabbits no significant difference. High-cholesterol ovariectomized rabbit Aβ Congo red staining. Our results suggest that supplemental estrogen lowering cholesterol may be effective in preventing AD.