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目的:探讨HBV感染的不同状态与HLA-DRB1等位基因之间的相关性。方法:采用聚合酶链反应/序列特异性引物技术(PCR/SSP)分别对慢性乙型肝炎组、HBV携带组、HBV感染后自然恢复组和正常对照组进行HLA-DRB1等位基因的检测。结果:HLA-DRB1觹1201/觹1501在慢性乙型肝炎组和HBV携带组出现的频率均明显高于正常对照组(均为P<0.01),HLA-DRB1觹1201在乙肝肝硬化患者、HLA-DRB1觹1501在原发性肝癌患者中出现的频率与正常对照组比较具有统计学意义(P<0.05,Pc<0.01)。结论:HLA-DRB1觹1201/觹1501可能是慢性乙型肝炎和HBV携带者的易感基因,而HLA-DRB1觹1201还可能是乙肝肝硬化的易感基因,HLA-DRB1觹1501可能是原发性肝癌的易感基因。
Objective: To investigate the relationship between different states of HBV infection and HLA-DRB1 alleles. Methods: HLA-DRB1 alleles were detected by polymerase chain reaction / sequence specific primer (PCR / SSP) in chronic hepatitis B patients, HBV carriers, spontaneous HBV recovery patients and normal controls. Results: The frequencies of HLA-DRB1 觹 1201 / 觹 1501 in patients with chronic hepatitis B and HBV carriers were significantly higher than those in healthy controls (all P <0.01). The frequency of HLA-DRB1 觹 1201 in patients with hepatitis B cirrhosis -DRB1 觹 1501 in patients with primary liver cancer frequency was statistically significant (P <0.05, P <0.01) compared with the normal control group. Conclusion: HLA-DRB1 觹 1201 / 觹 1501 may be susceptible genes of chronic hepatitis B and HBV carriers, and HLA-DRB1 觹 1201 may also be susceptible genes of hepatitis B cirrhosis. HLA-DRB1 觹 1501 may be the original Susceptibility gene of primary liver cancer.