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目的了解HPV阳性患者宫颈病变情况。方法调查431例HPV阳性患者TCT和阴道镜下定点活检病理诊断结果,分析人乳头瘤病毒基因型在宫颈疾病中的分布特点。结果 431例HPV阳性标本中正常组(包括炎症组)占阳性样本率为55.9%(241/431)、湿疣组为6.7%(29/431)、ASCUS组为10.4%(45/431)、LSIL组为11.8%(51/431)、HSIL组为10.6%(43/431)、SCC组为5.2%(22/431)。各亚型在不同病变中的分布不同,HR-HPV亚型阳性率随感染级别的严重程度而比例升高,除湿疣组外,其它组与正常组HR-HPV亚型阳性率比较,差异无统计学意义(P>0.05);湿疣组多重感染率为56.2%,其它组多重感染阳性率与正常组比较,差异无统计学意义(P>0.05);各组除LSIL组和湿疣组外均以HPV16亚型感染率最高,病变组中HSIL组与SCC组HPV16阳性率与正常组相比较,差异有统计学意义(P<0.05)。各病理级别年龄段感染率,主要以36~45岁年龄段感染为主。结论在宫颈病变中仍以高危亚型感染居多,多重感染可能并不增加宫颈癌的发生率。
Objective To understand the cervical lesions in patients with HPV-positive. Methods 431 cases of HPV-positive patients by TCT and colposcopy biopsy pathological diagnosis of the results, analysis of human papillomavirus genotype distribution in cervical disease characteristics. Results The positive rate of HPV positive specimens in 431 cases was 55.9% (241/431) in the normal group (6.7%), 6.7% (29/431) in the genital warts group, 10.4% (45/431) in the ASCUS group, The group was 11.8% (51/431), the HSIL group was 10.6% (43/431), and the SCC group was 5.2% (22/431). The distribution of subtypes was different in different pathological types. The positive rate of HR-HPV subtype was increased with the severity of infection level. The positive rates of HR-HPV subtype in other groups were lower than those in normal group (P> 0.05). The rate of multiple infection in genital warts was 56.2%. The positive rates of multiple infections in other groups were not significantly different from those in normal controls (P> 0.05) The infection rate of HPV16 subtype was the highest, the positive rate of HPV16 in HSIL group and SCC group was significantly higher than that in normal group (P <0.05). The infection rate of the age-class pathological level, mainly in the 36 to 45 age-based age-based infection. Conclusions Most cervical lesions are still infected with high-risk subtypes. Multiple infections may not increase the incidence of cervical cancer.