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目的观察自拟健脾降浊汤与西药联用治疗2型糖尿病胰岛素抵抗的临床疗效。方法将80例中医辨证为脾虚痰浊型的2型糖尿病胰岛素抵抗患者随机分为两组,对照组40例用二甲双胍肠溶片和瑞格列奈片治疗,治疗组40例在对照组基础上加服自拟健脾降浊汤,疗程为8周。主要观察治疗前后空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、胰岛素敏感性指数(ISI)、症状体征等指标的变化。结果治疗组和对照组临床有效率分别为85.0%、62.5%,两组疗效差异有统计学意义(P<0.05);在改善HbAlc、FINS、ISI和血脂方面,治疗组优于对照组(P<0.05)。结论健脾降浊汤联合西药治疗2型糖尿病胰岛素抵抗有良好的协同效应,能够降低血糖,改善胰岛素抵抗。
Objective To observe the clinical efficacy of Jianpi Jiangzhuo Decoction combined with western medicine in the treatment of type 2 diabetes mellitus with insulin resistance. Methods Eighty patients with type 2 diabetes mellitus with insulin resistance of phlegm and phlegm-turbidity type of TCM were randomly divided into two groups. The control group, 40 cases were treated with metformin enteric-coated tablets and repaglinide tablets. The treatment group 40 cases on the basis of the control group Plus take self spleen Jiangzhuo soup, treatment for 8 weeks. Mainly observe the changes of fasting blood glucose (FBG), HbA1c, FINS, TC, TG, HDL-C and LDL before and after treatment LDL-C), insulin sensitivity index (ISI), symptoms and signs and other indicators of change. Results The clinical effective rates of the treatment group and the control group were 85.0% and 62.5%, respectively, and there was significant difference between the two groups (P <0.05). The improvement of HbA1c, FINS, ISI and blood lipid in the treatment group was better than that in the control group <0.05). Conclusion Jianpijiangzhuo Decoction combined with Western medicine treatment of type 2 diabetes insulin resistance has a good synergistic effect, can reduce blood glucose and improve insulin resistance.