论文部分内容阅读
用ABC免疫组化方法检测了24例涎腺粘液表皮样癌c-erbB-2和nm23癌基因的表达。结果显示c-erbB-2癌基因表达阳性率41．67％，阳性染色主要见于表皮样细胞和中间细胞；高分化型与低分化型肿瘤间c-erbB-2癌基因表达差异有显著意义（P＜0．05）。nm23癌基因表达阳性率79．17％，阳性细胞主要为粘液细胞，高分化型与低分化型粘液表皮样癌nm23癌基因表达差异亦有显著意义（P＜0．05）。认为c-erbB-2和nm23癌基因表达可作为判断高分化型与低分化型涎腺粘液表皮样癌的指标。
Immunohistochemical ABC method was used to detect the expression of c-erbB-2 and nm23 oncogene in 24 cases of mucoepidermoid carcinoma of the salivary glands. The results showed that the positive rate of c-erbB-2 oncogene expression was 41.67%. The positive staining was mainly found in epidermoid cells and intermediate cells. The difference of c-erbB-2 oncogene expression between well-differentiated and poorly differentiated tumors was significant P <0.05). The positive rate of nm23 oncogene expression was 79.17%. The positive cells were predominantly mucoid cells. There was also significant difference in the expression of nm23 oncogene between well differentiated and poorly differentiated mucoepidermoid carcinoma (P <0.05). That c-erbB-2 and nm23 oncogene expression can be used as indicators to determine the well-differentiated and poorly differentiated salivary gland mucoepidermoid carcinoma.